[CAS NO. 908-54-3] Diminazene Aceturate

Name: Diminazene Aceturate
Brand: Arctom Scientific
SKU: SLK-S4104

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PRODUCTS SPECIFICATIONS [908-54-3]

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Catalog

SLK-S4104

Brand

Selleck

CAS

908-54-3

DESCRIPTION [908-54-3]

Overview

MDL	MFCD00058386
Molecular Weight	515.52
Molecular Formula	C14H15N7.2C4H7NO3
SMILES	C(=N)(N)C1=CC=C(N=NNC2=CC=C(C(=N)N)C=C2)C=C1.C(NC(C)=O)C(O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9398 mL	9.6989 mL	19.3979 mL
5 mM	0.3880 mL	1.9398 mL	3.8796 mL
10 mM	0.1940 mL	0.9699 mL	1.9398 mL
50 mM	0.0388 mL	0.1940 mL	0.3880 mL

Description

Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.

In vitro

Diminazene is capable of inhibiting the P2 transporter activity and this activity is lost in one diminazene-adapted trypanosome line, this does not formally prove that TbAT1 transports diminazene, nor does it establish whether transporter in addition to P2 could be involved in diminazene uptake. Diminazene is rapidly accumulated through a single transporter in T. brucei brucei 427 with K value of 0.45 μM. [H]Diminazene transport is also potently inhibited by pentamidine and adenosine, with K values of 0.21 μM and 0.25 μM, respectively. [3H]diminazene (2.5 μM) is clearly accumulated by yeast cells expressing TbAT1, with a rate of 0.0083 pmol/10 cell/s, and this process is completely inhibited by the presence of 1 mM unlabeled diminazene aceturate.

References

[1] de Koning HP, et al. Antimicrob Agents Chemother, 2004, 48(5), 1515-1519.
[2] Tuntasuvan D, et al. Vet Parasitol, 2003, 110(3-4), 227-233.
[3] Akpa PO, et al. Vet Parasitol, 2008, 151(2-4), 139-149.

Synonyms

Glycine, N-acetyl-, compd. with 4,4′-(1-triazene-1,3-diyl)bis[benzenecarboximidamide] (2:1)

Glycine, N-acetyl-, compd. with 4,4′-(diazoamino)dibenzamidine (2:1)

Glycine, N-acetyl-, compd. with 4,4′-(azoamino)dibenzamidine

Benzamidine, 4,4′-diazoaminodi-, diaceturate

Benzamidine, 4,4′-(diazoamino)di-, compd. with N-acetylglycine (1:2)

Benzenecarboximidamide, 4,4′-(1-triazene-1,3-diyl)bis-, compd. with N-acetylglycine (1:2)

Azidin

Azidine

Di-(4-amidinophenyl)-triazine-(N-1,3)-diaceturate

Berenil

Diminazene diaceturate

Diminazene aceturate

Diminazine aceturate

4,4′-Diamidinodiazoaminobenzene diaceturate

4,4′-(Diazoamino)dibenzamidine diaceturate

1,3-Bis(p-amidinophenyl)triazene bis(N-acetylglycinate)

1,3-Bis[4-guanylphenyl]triazene diaceturate

p,p′-Diguanyldiazoaminobenzene diaceturate

Ganasag

Ganaseg

Beronal

Diaminazene aceturate

Veriben

Diminazine diaceturate

Diminasan

Fatrybanil

Tricip Plus

Neozidin-M