[CAS NO. 93413-62-8] Desvenlafaxine

Name: Desvenlafaxine
Brand: Arctom Scientific
SKU: SLK-S4113

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PRODUCTS SPECIFICATIONS [93413-62-8]

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Catalog

SLK-S4113

Brand

Selleck

CAS

93413-62-8

DESCRIPTION [93413-62-8]

Overview

MDL	MFCD00871934
Molecular Weight	263.38
Molecular Formula	C16H25NO2
SMILES	C(CN(C)C)(C1(O)CCCCC1)C2=CC=C(O)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.7968 mL	18.9840 mL	37.9680 mL
5 mM	0.7594 mL	3.7968 mL	7.5936 mL
10 mM	0.3797 mL	1.8984 mL	3.7968 mL
50 mM	0.0759 mL	0.3797 mL	0.7594 mL

Description

Desvenlafaxine (WY 45233 Succinate) is a and reuptake inhibitor with of 40.2 nM and 558.4 nM, respectively.

Features

Desvenlafaxine is a major active metabolite of venlafaxine.

Targets

5-HT ^[1]	Norepinephrine (NE) ^[1]
40.2 nM(Ki)	558.4 nM(Ki)

In vitro

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [H]5-HT or [H]NE uptake for the hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively. Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Induction of CYP3A4 is also possible with desvenlafaxine, which could impact the metabolism of drugs metabolized via this enzyme.

In vivo

Desvenlafaxine rapidly penetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis. Desvenlafaxine exhibits a linear and dose-proportional pharmacokinetic single-dose profile in a dose range from 100 to 600 mg/day. The absolute bioavailability of the oral formulation is 80.5%.

References

[1] Deecher DC, et al. J Pharmacol Exp Ther, 2006, 318(2), 657-665.
[2] Sopko MA Jr, et al. Ann Pharmacother, 2008, 42(10), 1439-1446.

Synonyms

Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

O-Desmethylvenlafaxine

Desvenlafaxine

DVS 233

Pristiq

D-VENIZ

NEWVEN

MDD-XR

O-Desvenlafaxine