[CAS NO. 68786-66-3] Triclabendazole

Name: Triclabendazole
Brand: Arctom Scientific
SKU: SLK-S4114

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PRODUCTS SPECIFICATIONS [68786-66-3]

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Catalog

SLK-S4114

Brand

Selleck

CAS

68786-66-3

DESCRIPTION [68786-66-3]

Overview

MDL	MFCD03147039
Molecular Weight	359.66
Molecular Formula	C14 H9Cl3N2OS
SMILES	O(C=1C=C2C(N=C(SC)N2)=CC1Cl)C3=C(Cl)C(Cl)=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7804 mL	13.9020 mL	27.8040 mL
5 mM	0.5561 mL	2.7804 mL	5.5608 mL
10 mM	0.2780 mL	1.3902 mL	2.7804 mL
50 mM	0.0556 mL	0.2780 mL	0.5561 mL

Description

Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.

Features

Rapidly removed by the liver and oxidized to the sulphoxide and sulphone metabolites.

Targets

Tubulin ^[1]

In vitro

Triclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines.

References

[1] Moll L, et al. Vet Parasitol, 2000, 91(1-2), 153-158.
[2] Robinson MW, et al. Parasitology, 2002, 124(Pt 3), 325-338.
[3] Fairweather I, et al. J Helminthol, 2005, 79(3), 227-234.
[4] Hennessy DR, et al. J Vet Pharmacol Ther, 1987, 10(1), 64-72.
[5] Coles GC, et al. J Helminthol, 1986, 60(3), 210-212.

Synonyms

1H-Benzimidazole, 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-

1H-Benzimidazole, 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-

6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole

5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthiobenzimidazole

CGA 89317

Triclabendazole

5-Chloro-6-(2′,3′-dichlorophenoxy)-2-(methylthio)benzimidazole

Fasinex

Egaten