[CAS NO. 2624-44-4] Ethamsylate

Name: Ethamsylate
Brand: Arctom Scientific
SKU: SLK-S4152

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PRODUCTS SPECIFICATIONS [2624-44-4]

Store

Catalog

SLK-S4152

Brand

Selleck

CAS

2624-44-4

DESCRIPTION [2624-44-4]

Overview

MDL	MFCD00867499
Molecular Weight	263.31
Molecular Formula	C6H6O5S.C4H11N
SMILES	S(=O)(=O)(O)C1=C(O)C=CC(O)=C1.N(CC)CC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

Targets

prostaglandins ^[1]

In vitro

Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM. Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187.

In vivo

Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema.

References

[1] Kovács L, et al. Experientia, 1981, 37(11), 1182-1183
[2] Garay RP, et al. Am J Ther, 2006, 13(3), 236-247.

Synonyms

Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)

Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine (1:1)

Benzenesulfonic acid, 2,5-dihydroxy-, compd. with Et2NH

Diethylamine, 2,5-dihydroxybenzenesulfonate

Ethanamine, N-ethyl-, 2,5-dihydroxybenzenesulfonate

141 MD

Dicynene

Dicynone

Diethylammonium 2,5-dihydroxybenzenesulfonate

Ethamsylate

Cyclonamine

Eselin

Aglumin

Altodor

Etamsylate

2,5-Dihydroxybenzenesulfonic acid diethylamine salt

Dicinone

Biosinon

MD 141

E 141

K-Stat

Hemsyl

Sylate