[CAS NO. 24390-14-5] Doxycycline Hyclate (WC2031)

Name: Doxycycline Hyclate (WC2031)
Brand: Arctom Scientific
SKU: SLK-S4163

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PRODUCTS SPECIFICATIONS [24390-14-5]

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Catalog

SLK-S4163

Brand

Selleck

CAS

24390-14-5

DESCRIPTION [24390-14-5]

Overview

MDL	-
Molecular Weight	512.94
Molecular Formula	C22H24N2O8.1/2C2H6O.HCl.1/2H2O
SMILES	C(C)O.O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H].Cl.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9495 mL	9.7477 mL	19.4955 mL
5 mM	0.3899 mL	1.9495 mL	3.8991 mL
10 mM	0.1950 mL	0.9748 mL	1.9495 mL
50 mM	0.0390 mL	0.1950 mL	0.3899 mL

Description

Doxycycline Hyclate (WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate) is a member of the group, and is commonly used to treat a variety of infections. It is also an inhibitor of .

Targets

MMP ^[6]

In vitro

Doxycycline hyclate 10% (DOXY) has significant toxicity effects on osteoblast cells compared to the control group with a mean cell viability of 84%. Doxycycline hyclate 10% (DOXY) results in a significantly higher alkaline phosphatase activity (approximately 56%) than the control in osteoblasts. Doxycycline hyclate 10% (DOXY) seems to slightly altered the morphology of the osteoblasts.

References

[1] Almazin SM, et al. J Periodontol, 2009, 80(6), 999-1005.
[2] Breitschwerdt EB, et al. Antimicrob Agents Chemother, 1998, 42(2), 362-368.
[3] Perry HD, et al. Cornea, 1993, 12(5), 379-382.
[4] Zeidner NS, et al. Antimicrob Agents Chemother, 2004, 48(7), 2697-2699.
[5] Meijer LA, et al. Vet Q, 1993, 15(1), 1-5.
[6] Burggraf D, et al. Neurobiol Dis. 2007, 25(3):506-13.
[7] Li M, et al. Cell Metab. 2019 Sep 3;30(3):508-524.e12.

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)

2-Naphthacenecarboxamide, 4β-(dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6β-methyl-1,11-dioxo-, monohydrochloride, compd. with ethyl alc. (2:1), monohydrate

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5α,5aα,6α,12aα)]-, compd. with ethanol (2:1), monohydrate

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate

Ethanol, compd. with [4S-(4α,4aα,5α,5aα,6α,12aα)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate

Ethanol, compd. with (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate

Doxycycline hydrochloride hemiethanolate hemihydrate

Doxycycline hyclate

6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate

Atridox

Periostat

Monodoks

Tetraclean

BioPure MTAD

Doxyprex

DOX-T 100

DOXY 100

WC 2031

Doxitrat

Doryx