[CAS NO. 113712-98-4] Tenatoprazole

Name: Tenatoprazole
Brand: Arctom Scientific
SKU: SLK-S4212

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PRODUCTS SPECIFICATIONS [113712-98-4]

Store

Catalog

SLK-S4212

Brand

Selleck

CAS

113712-98-4

DESCRIPTION [113712-98-4]

Overview

MDL	MFCD00929085
Molecular Weight	346.4
Molecular Formula	C16H18N4O3S
SMILES	S(CC1=C(C)C(OC)=C(C)C=N1)(=O)C2=NC=3C(N2)=CC=C(OC)N3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Tenatoprazole (TU-199,STU-Na) is a prodrug of the inhibitor (PPI) class, which inhibits proton transport with of 3.2 μM. Tenatoprazole labels only the gastric alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.

Targets

Proton pump ^[1]	H(+),K(+)-ATPase ^[1] (Cell-free assay)
	3.2 μM

In vitro

Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain.

References

[1] Shin JM, et al. Biochem Pharmacol, 2006, 71(6), 837-849.

Synonyms

3H-Imidazo[4,5-b]pyridine, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

1H-Imidazo[4,5-b]pyridine, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-3H-imidazo[4,5-b]pyridine

TU 199

Tenatoprazole

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine

(±)-Tenatoprazole

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine

2-[2-[(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxyimidazo[4,5-b]pyridine