[CAS NO. 163521-08-2] Vilazodone HCl

Name: Vilazodone HCl
Brand: Arctom Scientific
SKU: SLK-S4259

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PRODUCTS SPECIFICATIONS [163521-08-2]

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Catalog

SLK-S4259

Brand

Selleck

CAS

163521-08-2

DESCRIPTION [163521-08-2]

Overview

MDL	MFCD00940014
Molecular Weight	477.99
Molecular Formula	C26H27N5O2.HCl
SMILES	C(CCCN1CCN(CC1)C=2C=C3C(=CC2)OC(C(N)=O)=C3)C=4C=5C(NC4)=CC=C(C#N)C5.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0921 mL	10.4605 mL	20.9209 mL
5 mM	0.4184 mL	2.0921 mL	4.1842 mL
10 mM	0.2092 mL	1.0460 mL	2.0921 mL
50 mM	0.0418 mL	0.2092 mL	0.4184 mL

Description

Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor () and a partial agonist of , used for the treatment of major depressive disorder.

Targets

SSRI ^[1]

5-HT1A ^[1]

In vitro

Vilazodone demonstrates an IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. Vilazodone displays high affinity (pKi ≥ 9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors.

References

[1] Dawson LA, et al. CNS Neurosci Ther, 2009, 15(2), 107-117.
[2] Hughes ZA, et al. Eur J Pharmacol, 2005, 510(1-2), 49-57.
[3] Adamec R, et al. Eur J Pharmacol, 2004, 504(1-2), 65-77.

Synonyms

2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1)

2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, monohydrochloride

Vilazodone hydrochloride

SB 659746A

EMD 68843

Viibryd