[CAS NO. 159989-65-8] Nelfinavir (AG 1343) Mesylate

Name: Nelfinavir (AG 1343) Mesylate
Brand: Arctom Scientific
SKU: SLK-S4282

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [159989-65-8]

Store

Catalog

SLK-S4282

Brand

Selleck

CAS

159989-65-8

DESCRIPTION [159989-65-8]

Overview

MDL	MFCD00931436
Molecular Weight	663.89
Molecular Formula	C33H49N3O7S2
SMILES	S(C)(=O)(=O)O.C(NC(C)(C)C)(=O)[C@H]1N(C[C@H]([C@@H](NC(=O)C2=C(C)C(O)=CC=C2)CSC3=CC=CC=C3)O)C[C@@]4([C@](C1)(CCCC4)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.5063 mL	7.5314 mL	15.0627 mL
5 mM	0.3013 mL	1.5063 mL	3.0125 mL
10 mM	0.1506 mL	0.7531 mL	1.5063 mL
50 mM	0.0301 mL	0.1506 mL	0.3013 mL

Description

Nelfinavir Mesylate (Viracept, AG1343) is a potent inhibitor with of 2 nM.

Targets

HIV protease ^[1]
(Cell-free assay)

2 nM(Ki)

In vivo

In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. Initial investigation of the compound in fed rats indicated an oral bioavailability of 43%. In contrast, the oral bioavailability was significantly reduced in fasted rats to 29%. Nelfinavir demonstrated significant oral bioavailabilability across a range of species including dogs (47%), marmosets (17%), and cynomolgus monkeys (26%). It has a long plasma half-life after oral dosing that is likely due to a combination of slow dissolution and absorption. nelfinavir is well absorbed in humans particularly when administered with food and possesses minimal and easily managed side effects.

References

[1] Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.

Synonyms

3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)

3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, [3S-[2(2S*,3S*),3α,4aβ,8aβ]]-, monomethanesulfonate (salt)

3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, monomethanesulfonate (salt)

AG 1343

Nelfinavir mesylate

Viracept

Nelfinavir mesilate

Nelfin

Nelfinivir