[CAS NO. 113-52-0] Imipramine HCl

Name: Imipramine HCl
Brand: Arctom Scientific
SKU: SLK-S4377

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PRODUCTS SPECIFICATIONS [113-52-0]

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Catalog

SLK-S4377

Brand

Selleck

CAS

113-52-0

DESCRIPTION [113-52-0]

Overview

MDL	MFCD00012669
Molecular Weight	316.87
Molecular Formula	C19H25ClN2
SMILES	C(CCN(C)C)N1C=2C(CCC=3C1=CC=CC3)=CC=CC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1559 mL	15.7793 mL	31.5587 mL
5 mM	0.6312 mL	3.1559 mL	6.3117 mL
10 mM	0.3156 mL	1.5779 mL	3.1559 mL
50 mM	0.0631 mL	0.3156 mL	0.6312 mL

Description

Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

In vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes.

References

[1] Obach RS, et al. Drug Metab Dispos, 1997, 25(12), 1359-1369.
[2] Lemoine A, et al. Mol Pharmacol, 1993, 43(5), 827-832.
[3] Teschemacher AG, et al. Br J Pharmacol, 1999, 128(2), 479-485.
[4] Papp M, et al. Psychopharmacology (Berl), 1994, 115(4), 441-446.
[5] Teixeira RC, et al. Pharmacol Biochem Behav, 2000, 65(4), 571-576.

Synonyms

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride (1:1)

5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride

G 22355

5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

N-(γ-Dimethylaminopropyl)iminodibenzyl hydrochloride

N-(3-Dimethylaminopropyl)iminodibenzyl hydrochloride

Imipramine hydrochloride

Tofranil

Imizine

Melipramine hydrochloride

Imizin

Imipramine monohydrochloride

Tofranile

Teperine

Feinalmin

Irmin

Novo-pramine

Timolet

Eupramin

Censtim

Censtin

Surplix

SK-Pramine

Imizinum

Pryleugan

Intalpram

Tipramine

Chrytemin

Apo-Imipramine

Praminil

Imidobenzyle

Iramil

Imidol

DIPD

Janimine

Imiprin

Impril

Imavate

Imilanyle

Efuranol

Promiben

Dimipressin

Deprinol

Presamine

Dyna-Zina

Depsol

Melipramin