[CAS NO. 480449-70-5] Edoxaban

Name: Edoxaban
Brand: Arctom Scientific
SKU: SLK-S4429

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PRODUCTS SPECIFICATIONS [480449-70-5]

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Catalog

SLK-S4429

Brand

Selleck

CAS

480449-70-5

DESCRIPTION [480449-70-5]

Overview

MDL	MFCD13195544
Molecular Weight	548.06
Molecular Formula	C24H30ClN7O4S
SMILES	N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8246 mL	9.1231 mL	18.2462 mL
5 mM	0.3649 mL	1.8246 mL	3.6492 mL
10 mM	0.1825 mL	0.9123 mL	1.8246 mL
50 mM	-	-	-

Description

Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.

Targets

Factor Xa ^[1] (Cell-free assay)	Prothrombinase ^[1] (Cell-free assay)
0.561 nM(Ki)	2.98 nM(Ki)

In vitro

The dual split protein (DSP) assay using Calu-3 cells is performed in the presence of various anticoagulants, including edoxaban.

References

[1] T Furugohri, et al. J Thromb Haemost. 2008 Sep;6(9):1542-9.
[2] Yamamoto M, et al. Viruses. 2020 Jun 10;12(6):629.

Synonyms

Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-

Ethanediamide, N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-

N¹-(5-Chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide

Edoxaban

DU 176

N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide