[CAS NO. 928659-70-5] Eliglustat hemitartrate

Name: Eliglustat hemitartrate
Brand: Arctom Scientific
SKU: SLK-S4433

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PRODUCTS SPECIFICATIONS [928659-70-5]

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Catalog

SLK-S4433

Brand

Selleck

CAS

928659-70-5

DESCRIPTION [928659-70-5]

Overview

MDL	MFCD22665712
Molecular Weight	959.17
Molecular Formula	C50H78N4O14
SMILES	[C@@H]([C@H](C(O)=O)O)(C(O)=O)O.[C@@H]([C@@H](CN1CCCC1)NC(CCCCCCC)=O)(O)C=2C=C3C(=CC2)OCCO3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.0426 mL	5.2128 mL	10.4257 mL
5 mM	0.2085 mL	1.0426 mL	2.0851 mL
10 mM	0.1043 mL	0.5213 mL	1.0426 mL
50 mM	0.0209 mL	0.1043 mL	0.2085 mL

Description

Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of with IC50 of 24 nM.

Targets

Glucosylceramide Synthase ^[1]
(Cell-free assay)

24 nM

In vitro

When treated gaucher disease neuronal progenitor cells (NPCs) with the GlcCer synthase inhibitors Eliglustat and the brain‐penetrant Ibiglustat, there are significant reductions in both, GlcCer and GlcSph levels in the mutant NPCs.

References

[1] Kerry Anne McEachern, et al. Mol Genet Metab. 2007 Jul;91(3):259-67.
[2] Srikanth MP, et al. Stem Cells Transl Med. 2021 Jul;10(7):1081-1094.

Synonyms

Octanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)

Eliglustat tartrate

Genz 112638

Eliglustat hemitartrate