[CAS NO. 1441674-54-9] Ledipasvir acetone

Name: Ledipasvir acetone
Brand: Arctom Scientific
SKU: SLK-S4434

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PRODUCTS SPECIFICATIONS [1441674-54-9]

Store

Catalog

SLK-S4434

Brand

Selleck

CAS

1441674-54-9

DESCRIPTION [1441674-54-9]

Overview

MDL	MFCD28167732
Molecular Weight	947.08
Molecular Formula	C52H60F2N8O7
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.

Targets

GT1b replicon ^[1] (Cell-free assay)	GT1a replicon ^[1] (Cell-free assay)
4 pM(EC50)	31 pM(EC50)

In vitro

Ledipasvir acetone induces HCV clearance, inhibits STAT3 protein levels and restores HNF4A expression.

References

[1] Aydin Y, et al. Cancers (Basel). 2019 Sep 20;11(10):1407.