[CAS NO. 29608-49-9] Almitrine mesylate

Name: Almitrine mesylate
Brand: Arctom Scientific
SKU: SLK-S4439

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PRODUCTS SPECIFICATIONS [29608-49-9]

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Catalog

SLK-S4439

Brand

Selleck

CAS

29608-49-9

DESCRIPTION [29608-49-9]

Overview

MDL	MFCD01679060
Molecular Weight	669.76
Molecular Formula	C28H37F2N7O6S2
SMILES	S(C)(=O)(=O)O.C(N1CCN(CC1)C=2N=C(NCC=C)N=C(NCC=C)N2)(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.4931 mL	7.4654 mL	14.9307 mL
5 mM	0.2986 mL	1.4931 mL	2.9861 mL
10 mM	0.1493 mL	0.7465 mL	1.4931 mL
50 mM	0.0299 mL	0.1493 mL	0.2986 mL

Description

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca-dependent K channel by decreasing its open probability with IC50 of 0.22 μM.

Targets

peripheral chemoreceptor ^[1]	Ca²⁺-dependent K⁺ channel ^[2] (Cell-free assay)
	0.22 μM

References

[1] P D Smith, et al. Drug Intell Clin Pharm. 1987 May;21(5):417-21.
[2] J R López-López, et al. Mol Pharmacol. 1998 Feb;53(2):330-9.

Synonyms

1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N²,N⁴-di-2-propen-1-yl-, methanesulfonate (1:2)

s-Triazine, 2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-, dimethanesulfonate

1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N′-di-2-propenyl-, dimethanesulfonate

1-(4,6-Bis(allylamino)-2-s-triazinyl)-4-(4,4′-difluorobenzhydryl)piperazine bis(methane sulfonate)

1-[4,6-Bis(allylamino)-s-triazin-2-yl]-4-(di-p-fluorobenzhydryl)piperazine bis(methanesulfonate)

1-(4,6-Diallylamino-2-triazinyl)-4-(di-p-fluorobenzhydryl)piperazine bis(methanesulfonate)

Almitrine bismethanesulfonate

Almitrine dimesylate

Vectarion

Almitrine bismesylate

Almitrine dimethanesulfonate

Almitrine mesylate