[CAS NO. 59-66-5] Acetazolamide

Name: Acetazolamide
Brand: Arctom Scientific
SKU: SLK-S4506

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PRODUCTS SPECIFICATIONS [59-66-5]

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Catalog

SLK-S4506

Brand

Selleck

CAS

59-66-5

DESCRIPTION [59-66-5]

Overview

MDL	-
Molecular Weight	222.25
Molecular Formula	C4H6N4O3S2
SMILES	S(N)(=O)(=O)C=1SC(NC(C)=O)=NN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.4994 mL	22.4972 mL	44.9944 mL
5 mM	0.8999 mL	4.4994 mL	8.9989 mL
10 mM	0.4499 mL	2.2497 mL	4.4994 mL
50 mM	0.0900 mL	0.4499 mL	0.8999 mL

Description

Acetazolamide (Diamox), , is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).

Targets

Carbonic anhydrase ^[4]

10 nM

In vitro

acetazolamide reduces invasiveness of cancer cells in vitro.

In vivo

Acetazolamide reduces inflammation-induced heat hyperalgesia, probably acting both peripherally and centrally. Acetazolamide shows significant inhibitory effect on angiogenesis in CAM and endothelial cell proliferation. Acetazolamide is clinically used to reduce intraocular pressure in glaucoma, to correct metabolic alkalosis, and to manage cerebral edema. Its treatment may also be beneficial as an adjunct to cancer chemotherapy, because it can produce additive tumor growth delays with anticancer drugs in vivo.

References

[1] Radhakrishnan R, et al. J Pharmacol Exp Ther. 2005, 313(2):921-927.
[2] Xiang Y,et al. Acta Pharmacol Sin. 2004, 25(6):812-816.
[3] Parkkila S, et al. Proc Natl Acad Sci U S A. 2000, 97(5):2220-2224.
[4] Hardman, J.G., et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996, p. 693.

Synonyms

Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-

Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-

N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide

5-Acetamide-1,3,4-thiadiazole-2-sulfonamide

2-Acetamido-5-sulfonamido-1,3,4-thiadiazole

Acetazolamide

Diacarb

Diamox

Diuramid

Edemox

Fonurit

Natrionex

Nephramide

Phonurit

5-Acetamido-1,3,4-thiadiazole-2-sulfonamide

2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide

Cidamex

Acetamox

Nephramid

Diutazol

Diluran

Glaupax

Donmox

Glupax

Dehydratin

5-Acetylamino-1,3,4-thiadiazol-2-ylsulfonamide

Diakarb

Acetazolamid

5-Acetamido-1,3,4-thiodiazole-2-sulfonamide

Eumicton

Diuramide

L 579486

N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

2-Acetamido-1,3,4-thiadiazole-5-sulfonamide

Atenezol

Diuriwas

Defiltran

Didoc

Carbonic anhydrase inhibitor 6063

Diureticum-Holzinger

NSC 145177

N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

AZM