[CAS NO. 42017-89-0] Fenofibric acid
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PRODUCTS SPECIFICATIONS [42017-89-0]
Store
Catalog
SLK-S4527
Brand
Selleck
CAS
42017-89-0
DESCRIPTION [42017-89-0]
Overview
| MDL | MFCD00792461 |
|---|---|
| Molecular Weight | 318.75 |
| Molecular Formula | C17H15ClO4 |
| SMILES | C(=O)(C1=CC=C(OC(C(O)=O)(C)C)C=C1)C2=CC=C(Cl)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1373 mL | 15.6863 mL | 31.3725 mL |
| 5 mM | 0.6275 mL | 3.1373 mL | 6.2745 mL |
| 10 mM | 0.3137 mL | 1.5686 mL | 3.1373 mL |
| 50 mM | 0.0627 mL | 0.3137 mL | 0.6275 mL |
Description
Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a , decreasing low-density lipoprotein cholesterol and triglycerides.
Targets
| PPARα [1] |
In vitro
Fibric acids, active forms of fibrate drugs and activators of peroxisome proliferator-activated receptor-alpha (PPARα), are also known for an HDL-raising effect. Fibric acids enhance fatty acid catabolism and accordingly reduce plasma lipid level, predominantly triglyceride (TG). Fenofibric acid increases the expression of ABCA1 and apoA-I–mediated HDL production. The effect on ABCA1 expression was through the enhancement of the transcription of the ABCA1 gene being dependent on LXR.
In vivo
Fenofibric acid attenuates aberrant increases of circulating EPC(Endothelial Progenitor Cells) in OIR mice. Inhibitory effect of Fenofibric acid on EPC mobilization in the OIR model is PPARα-dependent.Fenofibric acid Inhibits hypoxia-induced retinal EPC increase in a PPARα-dependent manner. Fenofibric acid decreases CXCR4-positive EPC in the circulation, downregulates the serum SDF-1 level and suppresses HIF-1a and SDF-1 overexpression in the retina.
References
Synonyms
Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid
2-[p-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
LF 178 acid
LF 153
2-[4′-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
Procetofenic acid
α-1081
Fenofibric acid
NSC 281318
FNF acid
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