[CAS NO. 138786-67-1] Pantoprazole sodium

Name: Pantoprazole sodium
Brand: Arctom Scientific
SKU: SLK-S4538

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [138786-67-1]

Store

Catalog

SLK-S4538

Brand

Selleck

CAS

138786-67-1

DESCRIPTION [138786-67-1]

Overview

MDL	MFCD01658543
Molecular Weight	405.35
Molecular Formula	C16H14F2N3NaO4S
SMILES	S(CC1=C(OC)C(OC)=CC=N1)(=O)C=2NC=3C(N2)=CC(OC(F)F)=CC3.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Pantoprazole (SKF96022, BY-1023) is a inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Targets

Proton pump ^[4]

HIF-1α ^[2]

(H+/K+)-ATPase ^[4]

In vitro

pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells.

In vivo

After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells.

References

[1] Shen Y, et al. Oncol Lett. 2016, 11(1):717-722.
[2] Shen Y, et al. Neoplasma. 2012, 59(2):142-149.
[3] Y Wu, et al. Chinese Journal of Gastroenterology. 2010, 15(4):205-208.
[4] Yeo M, et al. Clin Cancer Res. 2004, 10(24):8687-8696.

Synonyms

1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt

Pantoprazole sodium

Protonix

Controloc

Pantoloc

Pantoprazole sodium salt

Zurcal

5-Difluoromethoxy-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole sodium salt

Pantecta

Nolpaza

Somac