[CAS NO. 4008-48-4] Nitroxoline

Name: Nitroxoline
Brand: Arctom Scientific
SKU: SLK-S4591

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PRODUCTS SPECIFICATIONS [4008-48-4]

Store

Catalog

SLK-S4591

Brand

Selleck

CAS

4008-48-4

DESCRIPTION [4008-48-4]

Overview

MDL	MFCD00006791
Molecular Weight	190.16
Molecular Formula	C9H6N2O3
SMILES	N(=O)(=O)C=1C2=C(C(O)=CC1)N=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.2587 mL	26.2936 mL	52.5873 mL
5 mM	1.0517 mL	5.2587 mL	10.5175 mL
10 mM	0.5259 mL	2.6294 mL	5.2587 mL
50 mM	0.1052 mL	0.5259 mL	1.0517 mL

Description

Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting activity.

Targets

cathepsin B ^[2]

In vitro

Nitroxoline significantly reduces extracellular DQ-collagen IV degradation by all evaluated cancer cell lines using spectrofluorimetry. Nitroxoline also markedly decreases tumor cell invasion monitored in real time and reduces the invasive growth of multicellular tumor spheroids, used as a 3D in vitromodel of tumor invasion. Endothelial tube formation is significantly reduced by nitroxoline in an in vitro angiogenesis assay.

In vivo

Nitroxoline significantly abrogates tumor growth, angiogenesis and metastasis in vivo in LPB fibrosarcoma and MMTV-PyMT breast cancer mouse models.

References

[1] Mirković B, et al. Oncotarget. 2015, 6(22):19027-19042.
[2] Mirković B, et al. ChemMedChem. 2011, 6(8):1351-1356.

Synonyms

8-Quinolinol, 5-nitro-

5-Nitro-8-quinolinol

8-Hydroxy-5-nitroquinoline

5-Nitro-8-hydroxyquinoline

Nitroxoline

Nibiol

Nitroxolin

5-Nitro-8-oxyquinoline

5-Nitro-8-oxychinoline

5NOK

Noxibiol

5-Nitroxine

BAS 58

5-Nitrox

A 82

NSC 74947

NSC 74948

5-(Hydroxyl[oxido]amino)-8-hydroxyquinoline