[CAS NO. 77-67-8] Ethosuximide

Name: Ethosuximide
Brand: Arctom Scientific
SKU: SLK-S4626

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PRODUCTS SPECIFICATIONS [77-67-8]

Store

Catalog

SLK-S4626

Brand

Selleck

CAS

77-67-8

DESCRIPTION [77-67-8]

Overview

MDL	MFCD00072123
Molecular Weight	141.17
Molecular Formula	C7H11NO2
SMILES	C(C)C1(C)C(=O)NC(=O)C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	7.0837 mL	35.4183 mL	70.8366 mL
5 mM	1.4167 mL	7.0837 mL	14.1673 mL
10 mM	0.7084 mL	3.5418 mL	7.0837 mL
50 mM	0.1417 mL	0.7084 mL	1.4167 mL

Description

Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A blocker.

In vitro

Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation.

References

[1] Chen X, et al. Mol Neurodegener. 2015, 10:51.
[2] Collins JJ, et al. PLoS Genet. 2008, 4(10):e1000230.
[3] Tiwari SK, et al. J Biol Chem. 2015, 290(47):28540-28558.
[4] Coulter DA, et al. Ann Neurol. 1989, 25(6):582-93.

Synonyms

2,5-Pyrrolidinedione, 3-ethyl-3-methyl-

Succinimide, 2-ethyl-2-methyl-

3-Ethyl-3-methyl-2,5-pyrrolidinedione

C.I. 366

PM 671

Emeside

Ethosuxide

Ethosuximide

3-Ethyl-3-methylpyrrolidine-2,5-dione

2-Ethyl-2-methylsuccinimide

Petinimid

Petnidan

Succimitin

Suxinutin

Zarodan

Zarondan-Saft

Zarontin

α-Ethyl-α-methylsuccinimide

Simatin

Ronton

3-Methyl-3-ethylpyrrolidine-2,5-dione

Pyknolepsinum

Succimal

Capitus

Atysmal

Ethymal

Pemal

Mesentol

Suxilep

Suximal

Etosuximid

Piknolepsin

H 940

Zarondan

3-Ethyl-3-methylsuccinimide

α-Methyl-α-ethylsuccinimide

3-Methyl-3-ethylsuccinimide

2-Methyl-2-ethylsuccinimide

Epileo Petitmal

CN 10395

Peptinimid

NSC 64013

(±)-Ethosuximide