[CAS NO. 71441-28-6] TTNPB (Arotinoid Acid)

Name: TTNPB (Arotinoid Acid)
Brand: Arctom Scientific
SKU: SLK-S4627

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [71441-28-6]

Store

Catalog

SLK-S4627

Brand

Selleck

CAS

71441-28-6

DESCRIPTION [71441-28-6]

Overview

MDL	MFCD00673917
Molecular Weight	348.48
Molecular Formula	C24H28O2
SMILES	CC1(C)C=2C(C(C)(C)CC1)=CC=C(\C(=C\C3=CC=C(C(O)=O)C=C3)\C)C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8696 mL	14.3480 mL	28.6961 mL
5 mM	0.5739 mL	2.8696 mL	5.7392 mL
10 mM	0.2870 mL	1.4348 mL	2.8696 mL
50 mM	-	-	-

Description

TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is a potent agonist, and inhibits binding of [H]tRA with of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.

Targets

RARβ ^[1] (cell-free assay)	RARα ^[1] (cell-free assay)	RARγ ^[1] (cell-free assay)
4.5 nM	5.1 nM	9.3 nM

In vitro

TTNPB binds to nuclear retinoic acid receptors with high affinity, inhibits binding of [H]tRA with IC50 of 3.8 nM, 4.0 nM, and 4.5 nM for mRARα, β, and γ, respectively. TTNPB increases transcriptional activation of Mouse RARs in JEG-3 cells after 72 h using conditioned media with EC50 of 2.0 nM, 1.1 nM and 0.8 nM for mRARα, β, and γ, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle blockade. TTNPB causes a concentration-dependent decrease in ES-D3 cell differentiation.

In vivo

TTNPB (0.25 mg/kg) causes growth inhibition in both MXT-HS and MXT-HI models by inducing cell apoptosis.

References

[1] Pignatello MA, et al. Toxicol Appl Pharmacol. 1997, 142(2), 319-327.
[2] Pignatello MA, et al. Toxicol Appl Pharmacol. 1999, 159(2), 109-116.
[3] Wu K, et al. Breast Cancer Res Treat. 2006, 96(2), 147-157.
[4] Louisse J, et al. Toxicol Lett. 2011, 203(1), 1-8.
[5] Darro F, et al. Breast Cancer Res Treat. 1998, 51(1), 39-55.

Synonyms

Benzoic acid, 4-[(1E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]-

Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]-, (E)-

Benzoic acid, 4-[(1E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]-

4-[(1E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]benzoic acid

Ro 13-7410

Arotinoid acid

Arotinoid free acid

TTNPB

AGN 191183

TTNB

4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid