[CAS NO. 182004-65-5] KB-R7943 mesylate
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PRODUCTS SPECIFICATIONS [182004-65-5]
Store
Catalog
SLK-S4643
Brand
Selleck
CAS
182004-65-5
DESCRIPTION [182004-65-5]
Overview
| MDL | MFCD00952138 |
|---|---|
| Molecular Weight | 427.5 |
| Molecular Formula | C17H21N3O6S2 |
| SMILES | S(C)(=O)(=O)O.C(OC1=CC=C(CCSC(=N)N)C=C1)C2=CC=C(N(=O)=O)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3392 mL | 11.6959 mL | 23.3918 mL |
| 5 mM | 0.4678 mL | 2.3392 mL | 4.6784 mL |
| 10 mM | 0.2339 mL | 1.1696 mL | 2.3392 mL |
| 50 mM | 0.0468 mL | 0.2339 mL | 0.4678 mL |
Description
KB-R7943 mesylate is a widely used inhibitor of the reverse with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the pathway and blocking .
Targets
| NCX(rev) [1] (Cell-free assay) |
| 5.7 μM |
In vitro
KB-R7943 inhibits the reverse NCX more potently than its forward mode, thus occludes NCX-mediated Ca2+ extrusion and elevates intracellular Ca level of melanoma.
References
Synonyms
Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1)
Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, monomethanesulfonate
2-[4-[(4-Nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate methanesulfonate (1:1)
KB-R 7943
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