[CAS NO. 83-44-3] Deoxycholic acid
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PRODUCTS SPECIFICATIONS [83-44-3]
Store
Catalog
SLK-S4689
Brand
Selleck
CAS
83-44-3
DESCRIPTION [83-44-3]
Overview
| MDL | MFCD00003673 |
|---|---|
| Molecular Weight | 392.57 |
| Molecular Formula | C24H40O4 |
| SMILES | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5473 mL | 12.7366 mL | 25.4732 mL |
| 5 mM | 0.5095 mL | 2.5473 mL | 5.0946 mL |
| 10 mM | 0.2547 mL | 1.2737 mL | 2.5473 mL |
| 50 mM | 0.0509 mL | 0.2547 mL | 0.5095 mL |
Description
Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
In vitro
Deoxycholic acid inhibits miR-21 expression in primary rat hepatocytes in a dose-dependent manner, and increases miR-21 pro-apoptotic target programmed cell death 4 (PDCD4) and apoptosis. Deoxycholic acid decreases NF-κB activity, shown to represent an upstream mechanism leading to modulation of the miR-21/PDCD4 pathway.
In vivo
miR-21 expression is down-regulated upon short exposures to Deoxycholic acid, as is the downstream pathway, with concomitant PIDD processing and activation of caspase-2, which contributes to DCA-induced liver damage.
Synonyms
Cholan-24-oic acid, 3,12-dihydroxy-, (3α,5β,12α)-
5β-Cholan-24-oic acid, 3α,12α-dihydroxy-
(3α,5β,12α)-3,12-Dihydroxycholan-24-oic acid
Cholic acid, deoxy-
Cholorebic
Degalol
Deoxycholatic acid
Deoxycholic acid
Desoxycholic acid
3α,12α-Dihydroxycholanic acid
3α,12α-Dihydroxy-5β-cholanoic acid
Droxolan
17β-[1-Methyl-3-carboxypropyl]-etiocholane-3α,12α-diol
3α,12α-Dihydroxy-5β-cholanic acid
Cholerebic
Pyrochol
Septochol
3α,12α-Dihydroxy-5β-cholan-24-oic acid
5β-Deoxycholic acid
5β-Cholanic acid-3α,12α-diol
7-Deoxycholic acid
NSC 8797
ATX 101
Kybella
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