[CAS NO. 154-23-4] (+)-Catechin

Name: (+)-Catechin
Brand: Arctom Scientific
SKU: SLK-S4722

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PRODUCTS SPECIFICATIONS [154-23-4]

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Catalog

SLK-S4722

Brand

Selleck

CAS

154-23-4

DESCRIPTION [154-23-4]

Overview

MDL	MFCD00075649
Molecular Weight	290.27
Molecular Formula	C15H14O6
SMILES	O[C@@H]1[C@H](OC=2C(C1)=C(O)C=C(O)C2)C3=CC(O)=C(O)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.4451 mL	17.2253 mL	34.4507 mL
5 mM	0.6890 mL	3.4451 mL	6.8901 mL
10 mM	0.3445 mL	1.7225 mL	3.4451 mL
50 mM	0.0689 mL	0.3445 mL	0.6890 mL

Description

(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,

Targets

COX-1 ^[3] (Cell-based assay)	COX-2 ^[3] (Cell-based assay)
80 μM	130 μM

In vitro

The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM.

In vivo

Dietary catechin significantly delayed tumor onset. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse.

References

[1] Daniela Laura Papademetrio, et al. Rev bras farmacogn. 2013, 23(3):455-463.
[2] Tayyaba Afsar, et al. Scientific Reports 6. 2016, 23077.
[3] Noreen Y, et al. Planta Med. 1998, 64(6):520-4.
[4] Yin P, et al. Cancer Lett. 1994, 79(1):33-8.
[5] Ebeler SE, et al. Am J Clin Nutr. 2002, 76(4):865-72.
[6] Unno K, et al. Biogerontology. 2007, 8(2):89-95.
[7] Michael J, et al. Cancer research. 2001, 61:119-125.

Synonyms

2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-

Catechol

2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-

(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol

d-Catechin

(+)-Catechol

(+)-Catechin

(+)-(2R:3S)-5,7,3′,4′-Tetrahydroxyflavan-3-ol

Catechin

Catechinic acid

Catechuic acid

Catechol (flavan)

D-Catechol

D-(+)-Catechin

Catechin (flavan)

trans-(+)-3,3′,4′,5,7-Flavanpentol

(+)-3′,4′,5,7-Tetrahydroxy-2,3-trans-flavan-3-ol

3-Cyanidanol, (+)-

Catergen

(+)-Cyanidan-3-ol

(+)-Cyanidanol-3

Cianidanol

Cyanidanol

D-Catechin

(+)-Cianidanol

(+)-Cyanidanol

Biocatechin

Sunkatol No. 1

(2R,3S)-(+)-Catechin

Dexcyanidanol

Cyanidol

NSC 2819

Teafuran 30A

Teafuran 30E

HB-MC-TS 35

P 70A

(+)-(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol

Sunphenon 90

PP-S4-1