[CAS NO. 206184-49-8] Tenofovir hydrate
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PRODUCTS SPECIFICATIONS [206184-49-8]
Store
Catalog
SLK-S4879
Brand
Selleck
CAS
206184-49-8
DESCRIPTION [206184-49-8]
Overview
| MDL | MFCD11519982 |
|---|---|
| Molecular Weight | 305.23 |
| Molecular Formula | C9H16N5O5P |
| SMILES | C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2.O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2762 mL | 16.3811 mL | 32.7622 mL |
| 5 mM | 0.6552 mL | 3.2762 mL | 6.5524 mL |
| 10 mM | 0.3276 mL | 1.6381 mL | 3.2762 mL |
| 50 mM | - | - | - |
Description
Tenofovir (GS-1278) hydrate blocks and infections.
In vitro
Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT.
References
[6] Myriam Witvrouw, et al. Antivir Ther. 2004 Feb;9(1):57-65.
[1] Witvrouw M, et al. Antivir Ther. 2004 Feb;9(1):57-65.
[2] Miller MD, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1025-8.
[3] Ying C, et al. J Viral Hepat. 2000 Mar;7(2):161-5.
[4] Wainberg MA, et al. Antivir Ther. 1999;4(2):87-94.
[5] De Clercq E. Clin Microbiol Rev. 2003 Oct;16(4):569-96.
[1] Witvrouw M, et al. Antivir Ther. 2004 Feb;9(1):57-65.
[2] Miller MD, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1025-8.
[3] Ying C, et al. J Viral Hepat. 2000 Mar;7(2):161-5.
[4] Wainberg MA, et al. Antivir Ther. 1999;4(2):87-94.
[5] De Clercq E. Clin Microbiol Rev. 2003 Oct;16(4):569-96.
Synonyms
Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1)
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monohydrate, (R)-
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monohydrate
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