[CAS NO. 923288-90-8]  Nilotinib hydrochloride monohydrate

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PRODUCTS SPECIFICATIONS [923288-90-8]

Store
Catalog
SLK-S4895
Brand
Selleck
CAS
923288-90-8

DESCRIPTION [923288-90-8]

Overview

MDLMFCD18251359
Molecular Weight583.99
Molecular FormulaC28H25ClF3N7O2
SMILESO=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.[H]Cl.[H]O[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.7124 mL8.5618 mL17.1236 mL
5 mM0.3425 mL1.7124 mL3.4247 mL
10 mM0.1712 mL0.8562 mL1.7124 mL
50 mM0.0342 mL0.1712 mL0.3425 mL

Description

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces through activition.

Targets

AMPK [1]Bcr-Abl [1]
(in Murine myeloid progenitor cells)
30 nM