[CAS NO. 1101854-58-3] JZL184

Name: JZL184
Brand: Arctom Scientific
SKU: SLK-S4904

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PRODUCTS SPECIFICATIONS [1101854-58-3]

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Catalog

SLK-S4904

Brand

Selleck

CAS

1101854-58-3

DESCRIPTION [1101854-58-3]

Overview

MDL	-
Molecular Weight	520.49
Molecular Formula	C27H24N2O9
SMILES	C(O)(C=1C=C2C(=CC1)OCO2)(C=3C=C4C(=CC3)OCO4)C5CCN(C(OC6=CC=C(N(=O)=O)C=C6)=O)CC5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9213 mL	9.6063 mL	19.2127 mL
5 mM	0.3843 mL	1.9213 mL	3.8425 mL
10 mM	0.1921 mL	0.9606 mL	1.9213 mL
50 mM	0.0384 mL	0.1921 mL	0.3843 mL

Description

JZL 184 is the first selective inhibitor of with of 8 nM.

Targets

MAGL ^[1]

8 nM

In vitro

JZL184 is a useful tool for studying the effects of endogenous 2-AG signaling. JZL184 displays time-dependent inhibition of MAGL and exhibits >300-fold selectivity for MAGL over FAAH in vitro. JZL184 does not interact with CB1 or CB2 receptors and does not inhibit the 2-AG biosynthetic enzymes diacylglycerol lipase-αand diacylglycerol lipase-β, or the arachidonic acid–mobilizing enzyme cytosolic phospholipase A2 group IVA.

In vivo

JZL184 produced a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in eight-fold elevations in endogenous 2-AG levels that are maintained for at least 8 h. JZL184-treated mice showed a wide array of CB1-dependent behavioral effects, including analgesia, hypomotility and hypothermia, that suggest a broad role for 2-AG–mediated endocannabinoid signaling throughout the mammalian nervous system.

References

[1] Long JZ, et al. Nat Chem Biol, 2009, 5(1), 37-44.
[2] Ye L, et al. Cancer Lett, 2011, 307(1), 6-17.

Synonyms

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester

JZL 184