[CAS NO. 283173-50-2] Rucaparib

Name: Rucaparib
Brand: Arctom Scientific
SKU: SLK-S4948

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PRODUCTS SPECIFICATIONS [283173-50-2]

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Catalog

SLK-S4948

Brand

Selleck

CAS

283173-50-2

DESCRIPTION [283173-50-2]

Overview

MDL	MFCD11977252
Molecular Weight	323.36
Molecular Formula	C19H18FN3O
SMILES	O=C1C2=C3C(=C(NC3=CC(F)=C2)C4=CC=C(CNC)C=C4)CCN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Rucaparib (Rubraca, AG014699, PF01367338) is an inhibitor of with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

Targets

PARP1 ^[1]
(Cell-free assay)

1.4 nM(Ki)

In vitro

Rucaparib, the PARP inhibitor, exhibits a synergetic antiproliferative effect by enhancing apoptosis and DNA damage and reducing HR repair in BRCA-proficient GBM when combined with PI3K inhibitor BKM120.

References

[1] Huw D Thomas, et al. Mol Cancer Ther. 2007 Mar;6(3):945-56.
[2] Zhang S, et al. Cell Death Dis. 2021;12(6):546.

Synonyms

6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-

6H-Azepino[5,4,3-cd]indol-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-

8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

8-Fluoro-2-[4-[(methylamino)methyl]phenyl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one

Rucaparib

Rubraca