[CAS NO. 125-46-2] Usnic acid

Name: Usnic acid
Brand: Arctom Scientific
SKU: SLK-S4953

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PRODUCTS SPECIFICATIONS [125-46-2]

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Catalog

SLK-S4953

Brand

Selleck

CAS

125-46-2

DESCRIPTION [125-46-2]

Overview

MDL	MFCD00065294
Molecular Weight	344.32
Molecular Formula	C18H16O7
SMILES	CC12C=3C(OC1=CC(=O)C(C(C)=O)C2=O)=C(C(C)=O)C(O)=C(C)C3O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL
50 mM	-	-	-

Description

Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated and signaling pathways.

Targets

Akt ^[3]

ERK ^[3]

In vitro

Usnic acid inhibits cell growth involving G0/G1 phase cell cycle arrest and induces cell death via mitochondrial membrane depolarization and induction of apoptosis in human lung carcinoma cells. Usnic acid has shown activity againstmany cancer cells such as lung carcinoma cells, murine leukemia P388 and L1210 cells, colon carcinoma HT-29 and HCT-116 cells, breast adenocarcinoma MCF-7 cells, and cervix adenocarcinoma cells. Usnic acid also selectively inhibits the viability of human breast cancer MCF-7 cells in a concentration- and time-dependent manner, provoking the generation of reactive oxygen species (ROS), which triggers the mitochondrial/caspase apoptotic pathway in MCF-7 cells.

References

[1] Singh N, et al. Nutr Cancer. 2013, 65, Suppl 1:36-43.
[2] Shu-ting Zuo, et al. RSC Adv. 2015, 5: 153-162.
[3] Yajuan Song, et al. Angiogenesis . 2012 Sep;15(3):421-32.

Synonyms

1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-

Usnic acid

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione

Usno

Usnein

Usniacin

(±)-Usnic acid

NSC 8517

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione