[CAS NO. 1380575-43-8] Ceritinib dihydrochloride
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PRODUCTS SPECIFICATIONS [1380575-43-8]
Store
Catalog
SLK-S4967
Brand
Selleck
CAS
1380575-43-8
DESCRIPTION [1380575-43-8]
Overview
| MDL | MFCD26142928 |
|---|---|
| Molecular Weight | 631.06 |
| Molecular Formula | C28H38Cl3N5O3S |
| SMILES | O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O.[H]Cl.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits , and with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.
Targets
In vitro
LDK378 shows great anti-proliferative activity in Ba/F3-NPM-ALK and Karpas290 cells with IC50 of 26.0 nM and 22.8 nM, compared with IC50 of 319.5 nM and 2477 nM in Ba/F3-Tel-InsR and Ba/F3-WT cells.
References
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