[CAS NO. 111011-63-3] Efonidipine

Name: Efonidipine
Brand: Arctom Scientific
SKU: SLK-S4977

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PRODUCTS SPECIFICATIONS [111011-63-3]

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Catalog

SLK-S4977

Brand

Selleck

CAS

111011-63-3

DESCRIPTION [111011-63-3]

Overview

MDL	MFCD00865899
Molecular Weight	631.66
Molecular Formula	C34H38N3O7P
SMILES	C(OCCN(CC1=CC=CC=C1)C2=CC=CC=C2)(=O)C=3C(C(=C(C)NC3C)P4(=O)OCC(C)(C)CO4)C5=CC(N(=O)=O)=CC=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.5831 mL	7.9157 mL	15.8313 mL
5 mM	0.3166 mL	1.5831 mL	3.1663 mL
10 mM	0.1583 mL	0.7916 mL	1.5831 mL
50 mM	0.0317 mL	0.1583 mL	0.3166 mL

Description

Efonidipine (NZ-105) is an blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.

Targets

T-type calcium channel ^[2]

In vitro

Although efonidipine is not a specific T-type calcium channe (TTCC) blocker as it could also block L-type calcium channe (LTCC), its efficacy in blocking TTCC is much greater than that of LTCC. Efonidipine exerts an inhibitory effect on aldosterone synthesis and secretion in a human adrenocortical cell line (H295R), an effect that is mediated, at least in part, by suppression of 11-β-hydroxylase and aldosterone synthase expression. Efonidipine also suppresses both Ang II- and K+-induced aldosterone secretion, but it blocks the latter at much lower concentrations than the former.

In vivo

Efonidipine could provide broader beneficial effects including the heart, liver, and plasma, and antioxidant in iron-overload condition in both WT(muβ) and HT(muβ,) mice.

References

[1] Kumfu S, et al. Eur J Haematol. 2012, 88(6):535-48.
[2] Imagawa K, et al. J Cardiovasc Pharmacol. 2006, 47(1):133-8.

Synonyms

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, P-oxide

1,3,2-Dioxaphosphorinane, 3-pyridinecarboxylic acid deriv.

Efonidipine

(±)-Efonidipine

Landel