[CAS NO. 109889-09-0] Granisetron

Name: Granisetron
Brand: Arctom Scientific
SKU: SLK-S5052

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PRODUCTS SPECIFICATIONS [109889-09-0]

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Catalog

SLK-S5052

Brand

Selleck

CAS

109889-09-0

DESCRIPTION [109889-09-0]

Overview

MDL	-
Molecular Weight	312.41
Molecular Formula	C18H24N4O
SMILES	C(N[C@H]1C[C@@H]2N(C)[C@H](C1)CCC2)(=O)C=3C=4C(N(C)N3)=CC=CC4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2009 mL	16.0046 mL	32.0092 mL
5 mM	0.6402 mL	3.2009 mL	6.4018 mL
10 mM	0.3201 mL	1.6005 mL	3.2009 mL
50 mM	-	-	-

Description

Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.

Targets

5HT-3 ^[1]

In vitro

In radioligand binding studies on rat brain membranes, BRL 43694 had little or no affinity for 5-HT1A, 5-HT1B , 5-HT2 or for many other binding sites.

References

[1] Sanger GJ, et al. Eur J Pharmacol. 1989, 159(2):113-24.

Synonyms

1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-

1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo-

9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.

1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide

Granisetron

BRL 43694

BRL 43964

Kevatril

endo-Granisetron

Sustol

APF 530

Sancuso