[CAS NO. 178307-42-1] Revaprazan Hydrochloride

Name: Revaprazan Hydrochloride
Brand: Arctom Scientific
SKU: SLK-S5058

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PRODUCTS SPECIFICATIONS [178307-42-1]

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Catalog

SLK-S5058

Brand

Selleck

CAS

178307-42-1

DESCRIPTION [178307-42-1]

Overview

MDL	-
Molecular Weight	398.9
Molecular Formula	C22H23FN4.HCl
SMILES	CC1N(C2=C(C)C(C)=NC(NC3=CC=C(F)C=C3)=N2)CCC4=C1C=CC=C4.[H]Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Revaprazan Hydrochloride (YH1885) is a new reversible inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits via binding to the K+-binding site of the pump.

Targets

Proton pump ^[1]

H(+)/K(+)-ATPase ^[1]

In vitro

Revaprazan Hydrochloride reversibly inhibits H+/K+-ATPase via binding to the K+-binding site of the pump. This reversibility leads to fewer adverse events. Revaprazan could inhibit H.pylori-induced COX-2 expression by blocking phosphorylation of IκB-α and Akt signaling in AGS cells. It could impose significant anti-inflammatory actions on H.pylori infection beyond acid suppression.

In vivo

Pharmacokinetic studies of revaprazan hydrochloride in rats and dogs showed the drug had a low oral bioavailability, which was speculated to be due to first pass effect and poor water solubility of drug.

References

[1] Li W, et al. Int J Pharm. 2011, 408(1-2):157-62.
[2] Lee JS, et al. J Clin Biochem Nutr. 2012, 51(2):77-83.