[CAS NO. 1009119-65-6] Daclatasvir Dihydrochloride

Name: Daclatasvir Dihydrochloride
Brand: Arctom Scientific
SKU: SLK-S5062

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PRODUCTS SPECIFICATIONS [1009119-65-6]

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Catalog

SLK-S5062

Brand

Selleck

CAS

1009119-65-6

DESCRIPTION [1009119-65-6]

Overview

MDL	-
Molecular Weight	811.8
Molecular Formula	C40H50N8O6.2HCl
SMILES	C([C@@H](NC(OC)=O)C(C)C)(=O)N1[C@@H](CCC1)C=2NC(=CN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C=5NC(=NC5)[C@H]6N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC6.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.2318 mL	6.1592 mL	12.3183 mL
5 mM	0.2464 mL	1.2318 mL	2.4637 mL
10 mM	0.1232 mL	0.6159 mL	1.2318 mL
50 mM	0.0246 mL	0.1232 mL	0.2464 mL

Description

Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the used for the treatment of chronic HCV genotype 1 and 3 infection.

Targets

NS5A ^[1]

In vitro

Daclatasvir exhibited potent inhibition in all of the wild-type replicons and hybrid replicons representing the range of genotypes and subtypes. daclatasvir induces an alteration in the subcellular localization of NS5A, which inhibits the formation and activation of HCV RCs. Daclatasvir was found to have a high potency across all HCV genotypes with half-maximum effective concentrations (EC50) ranging from 9 to 146 pM. While it is pangenotypic, it has a low barrier to resistance against the subtype of Genotype 1a.

In vivo

Daclatasvir has good bioavailability in rats, dogs and cynomolgus monkey (F%= 50, 108 and 38 respectively).

References

[1] Lee JS, et al. J Clin Biochem Nutr. 2012, 51(2):77-83.
[2] Herbst DA, et al. Expert Opin Investig Drugs. 2013, 22(10):1337-46.

Synonyms

Carbamic acid, N,N′-[[1,1′-biphenyl]-4,4′-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C′-dimethyl ester, hydrochloride (1:2)

Daclatasvir dihydrochloride

BMS 790052-05

Daklinza