[CAS NO. 114798-26-4] Losartan

Name: Losartan
Brand: Arctom Scientific
SKU: SLK-S5067

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PRODUCTS SPECIFICATIONS [114798-26-4]

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Catalog

SLK-S5067

Brand

Selleck

CAS

114798-26-4

DESCRIPTION [114798-26-4]

Overview

MDL	MFCD00865831
Molecular Weight	422.91
Molecular Formula	C22H23ClN6O
SMILES	C(N1C(CCCC)=NC(Cl)=C1CO)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3646 mL	11.8228 mL	23.6457 mL
5 mM	0.4729 mL	2.3646 mL	4.7291 mL
10 mM	0.2365 mL	1.1823 mL	2.3646 mL
50 mM	0.0473 mL	0.2365 mL	0.4729 mL

Description

Losartan(DuP-753) is a selective, orally administered, nonpeptide blocker of used to treat high blood pressure, diabetic kidney disease, heart failure, and left ventricular enlargement.

Targets

AT1 receptor ^[1]

20 nM

In vitro

In vitro, losartan competes with the binding of angiotensin II to AT1 receptors; the concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nmol/L. Losartan increases AMPK phosphorylation in a time- and dose-dependent manner in VSMCs. It also increases ACC phosphorylation, a major downstream target protein in the AMPK signaling cascade, and LKB1 phosphorylation, which is an upstream kinase of AMPK. Losartan increases p53 and p21 expression in a time-dependent manner, whereas the levels of p27 are not changed. Losartan suppresses Ang II-induced Rb phosphorylation, as well as cyclin D and cyclin E expression which are required for cell cycle progression. The mechanism of growth suppression by losartan is therefore G0/G1 cell cycle arrest which is reversed by AMPK inhibition, such as compound C or AMPK siRNA, but not by apoptosis.

References

[1] Burnier M. Circulation. 2001, 103(6):904-12.
[2] Jung Eun Kim, et al. Korean J Physiol Pharmacol. 2010, 14(5): 299–304.
[3] Yao EH, et al. Hypertens Res. 2007, 30(11):1119-28.

Synonyms

1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-

1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-

2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol

DUP 89

Losartan

Lortaan

2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol

Angizaar

Allisartan

1-[1-[[2′-(2H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-butyl-4-chloro-1H-imidazol-5-yl]methanol

Lozap

Xartan

[2-Butyl-5-chloro-3-[2′-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl]-methanol

[2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol

[2-Butyl-4-chloro-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-imidazol-5-yl]methanol