[CAS NO. 564-25-0] Doxycycline

Name: Doxycycline
Brand: Arctom Scientific
SKU: SLK-S5159

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PRODUCTS SPECIFICATIONS [564-25-0]

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Catalog

SLK-S5159

Brand

Selleck

CAS

564-25-0

DESCRIPTION [564-25-0]

Overview

MDL	-
Molecular Weight	444.43
Molecular Formula	C22H24N2O8
SMILES	O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2501 mL	11.2504 mL	22.5007 mL
5 mM	0.4500 mL	2.2501 mL	4.5001 mL
10 mM	0.2250 mL	1.1250 mL	2.2501 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL

Description

Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific inhibitor.

In vitro

100 ng/mL-5 µg/mL Dox can significantly alter the metabolic profile of the cell, as well as reduce the proliferative rate, though the effect size depends upon the particular cell line used.Doxycycline arrests cells in G1-S phase of the cell cycle in PANC-1 cells and induces the expression of p53 and its downstream target p21. It down-regulates antiapoptotic genes and induces proapoptotic genes. Doxycycline also induces apoptosis through a Fas/Fas-ligand dependent pathway in Jurkat T lymphocytes.

References

[1] Ahler E, et al. PLoS One. 2013, 8(5):e64561.
[2] Son K, et al. Anticancer Res. 2009, 29(10):3995-4003.

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,6α,12aα)]-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Oxytetracycline, 6-deoxy-

α-6-Deoxy-5-hydroxytetracycline

Vibravenos

Doxycycline

6-Deoxyoxytetracycline

6-Deoxy-5-hydroxytetracycline

α-Doxycycline

α-6-Deoxyoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

GS 3065

Liviatin

Vibramycin

Doxytetracycline

Hydramycin

Deoxymykoin

Ronaxan

Doxycen

Doxivetin

Vibramycine

Monodox

Unidox

Tolexine

Vibranos SF

Doxinyl

Vibraveineuse

Pulmodox

Dentistar

Medeomycin

Doximal

Dotur

Doxy RW

Doxy-Gel

Polodoksin

Doxymycin

(-)-Doxycycline

Ceedox

Bidox-DT

Doxicip

Emdox

Idoxy

Lupidox

Lenteclin

Tetradox

Pdox-LB

R-Doxy

Doxirobe