[CAS NO. 22161-81-5] S-(+)-Ketoprofen

Name: S-(+)-Ketoprofen
Brand: Arctom Scientific
SKU: SLK-S5192

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PRODUCTS SPECIFICATIONS [22161-81-5]

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Catalog

SLK-S5192

Brand

Selleck

CAS

22161-81-5

DESCRIPTION [22161-81-5]

Overview

MDL	MFCD00673316
Molecular Weight	254.28
Molecular Formula	C16H14O3
SMILES	C(=O)(C1=CC([C@@H](C(O)=O)C)=CC=C1)C2=CC=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9327 mL	19.6634 mL	39.3267 mL
5 mM	0.7865 mL	3.9327 mL	7.8653 mL
10 mM	0.3933 mL	1.9663 mL	3.9327 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL

Description

S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.

Targets

COX-1 ^[1] (Cell-free assay)	COX-2 ^[1] (Cell-free assay)
1.9 nM	27 nM

In vitro

Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining.

References

[1] Liu S, et al. Biochem Biophys Res Commun,?007, 364(3), 650-655.
[2] Li KL, et al. J Periodontal Res, 1996, 31(8), 525-532.
[3] Owens JG, et al. Equine Vet J, 1995, 27(4), 296-300.
[4] Ting ST, et al. J Anim Sci, 2003, 81(5), 1281-1293.
[5] Rao KV, et al. Carcinogenesis,1996, 17(7), 1435-1438.
[6] A Palomer, et al. J Med Chem. 2000 Jun 1;43(11):2280-4.

Synonyms

Benzeneacetic acid, 3-benzoyl-α-methyl-, (αS)-

Benzeneacetic acid, 3-benzoyl-α-methyl-, (S)-

Hydratropic acid, m-benzoyl-, (+)-

(αS)-3-Benzoyl-α-methylbenzeneacetic acid

(+)-Ketoprofen

(S)-Ketoprofen

(+)-3-Benzoylhydratropic acid

(+)-2-(3-Benzoylphenyl)propionic acid

(2S)-2-(3-Benzoylphenyl)propionic acid

Dexketoprofen

(+)-(S)-m-Benzoylhydratropic acid

(S)-(+)-2-(3-Benzoylphenyl)propionic acid

(S)-2-(3-Benzoylphenyl)propionic acid

(+)-3-Benzoyl-α-methylbenzeneacetic acid

S-(+)-Ketoprofen

(S)-2-(3-Benzoylphenyl)propanoic acid

Arveles

(2S)-2-(3-Benzoylphenyl)propanoic acid