[CAS NO. 1859053-21-6] Rucaparib Camsylate

Name: Rucaparib Camsylate
Brand: Arctom Scientific
SKU: SLK-S5195

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PRODUCTS SPECIFICATIONS [1859053-21-6]

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Catalog

SLK-S5195

Brand

Selleck

CAS

1859053-21-6

DESCRIPTION [1859053-21-6]

Overview

MDL	-
Molecular Weight	555.66
Molecular Formula	C29H34FN3O5S
SMILES	C(S(=O)(=O)O)[C@@]12C(C)(C)[C@@H](CC1=O)CC2.O=C1C2=C3C(=C(NC3=CC(F)=C2)C4=CC=C(CNC)C=C4)CCN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7997 mL	8.9983 mL	17.9966 mL
5 mM	0.3599 mL	1.7997 mL	3.5993 mL
10 mM	0.1800 mL	0.8998 mL	1.7997 mL
50 mM	0.0360 mL	0.1800 mL	0.3599 mL

Description

Rucaparib (Rubraca, AG014699, PF01367338) Camsylate is an inhibitor of with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

Targets

PARP1 ^[1]
(Cell-free assay)

1.4 nM(Ki)

In vitro

Deletion of ATM does not impact sensitivity to PARP inhibition by rucaparib.

References

[1] Huw D Thomas, et al. Mol Cancer Ther. 2007 Mar;6(3):945-56.
[2] Rafiei S, et al. Cancer Res. 2020 Jun 1;80(11):2094-2100.

Synonyms

Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1)