[CAS NO. 17374-26-4] TBB

Name: TBB
Brand: Arctom Scientific
SKU: SLK-S5265

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PRODUCTS SPECIFICATIONS [17374-26-4]

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Catalog

SLK-S5265

Brand

Selleck

CAS

17374-26-4

DESCRIPTION [17374-26-4]

Overview

MDL	MFCD06411399
Molecular Weight	434.71
Molecular Formula	C6HBr4N3
SMILES	BrC1=C(NN=N2)C2=C(Br)C(Br)=C1Br

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3004 mL	11.5019 mL	23.0038 mL
5 mM	0.4601 mL	2.3004 mL	4.6008 mL
10 mM	0.2300 mL	1.1502 mL	2.3004 mL
50 mM	0.0460 mL	0.2300 mL	0.4601 mL

Description

TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.

Targets

CK2 ^[1] (Cell-free assay)	CK1 ^[1] (Cel-free assay)
0.4 μM(Ki)	47 μM(Ki)

In vitro

In the presence of 10 μM TBB (and 100 μM ATP) only CK2 was drastically inhibited (s85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3L and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC50 values one-two orders of magnitude higher than CK2 (IC50 = 0.9 μM). TBB discriminates between CK2 and CK1, being much more e¡ective with the former.

References

[1] Sarno S, et al. FEBS Lett. 2001, 496(1):44-8.