[CAS NO. 6631-94-3] 2-Acetylphenothiazine (ML171)
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PRODUCTS SPECIFICATIONS [6631-94-3]
Store
Catalog
SLK-S5304
Brand
Selleck
CAS
6631-94-3
DESCRIPTION [6631-94-3]
Overview
| MDL | MFCD00005017 |
|---|---|
| Molecular Weight | 241.31 |
| Molecular Formula | C14H11NOS |
| SMILES | C(C)(=O)C=1C=C2C(SC=3C(N2)=CC=CC3)=CC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1440 mL | 20.7202 mL | 41.4405 mL |
| 5 mM | 0.8288 mL | 4.1440 mL | 8.2881 mL |
| 10 mM | 0.4144 mL | 2.0720 mL | 4.1440 mL |
| 50 mM | 0.0829 mL | 0.4144 mL | 0.8288 mL |
Description
2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
Targets
In vitro
ML171 is a potent and selective inhibitor of NOX1, with an IC50 of 129–156 nM in cell-based assays. ML171 is not cytotoxic, and is selective among NOX family members NOX2, NOX3, and NOX4, as well as against xanthine oxidase, another cellular source of ROS. In addition, ML171 is highly effective in inhibiting the cellular production of invadopodia in a human colon cancer cell line. It strongly blocks ROS generation in HT29 cells (IC50HT29 = 0.129 μM). ML171 does not inhibit mitochondrial ROS production.
References
Synonyms
Ethanone, 1-(10H-phenothiazin-2-yl)-
Ketone, methyl phenothiazin-2-yl
1-(10H-Phenothiazin-2-yl)ethanone
2-Acetylphenothiazine
2-Acetyl-10H-phenothiazine
NSC 169669
NSC 57951
1-(10H-Phenothiazin-2-yl)ethan-1-one
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