[CAS NO. 56396-35-1] UK 5099
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PRODUCTS SPECIFICATIONS [56396-35-1]
Store
Catalog
SLK-S5317
Brand
Selleck
CAS
56396-35-1
DESCRIPTION [56396-35-1]
Overview
| MDL | MFCD19443867 |
|---|---|
| Molecular Weight | 288.30 |
| Molecular Formula | C18H12N2O2 |
| SMILES | C(=C(C(O)=O)C#N)C1=CN(C=2C1=CC=CC2)C3=CC=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4686 mL | 17.3430 mL | 34.6861 mL |
| 5 mM | 0.6937 mL | 3.4686 mL | 6.9372 mL |
| 10 mM | 0.3469 mL | 1.7343 mL | 3.4686 mL |
| 50 mM | 0.0694 mL | 0.3469 mL | 0.6937 mL |
Description
UK5099 (PF-1005023) is a potent inhibitor of the , inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM.
Targets
| mitochondrial pyruvate carrier [1] |
| 49 μM(Ki) |
In vitro
UK5099 covalently binds to Mpc and blocks pyruvate transport. UK5099 enhances aerobic glycolysis and decreases mitochondrial oxidative phosphorylation in LnCap cell in vitro, which is accompanied by increasing proportion of side population (SP) fraction, higher level of stemness markers expression and exhibiting high resistance to chemotherapy. UK5099 enhances stem-like phenotype of prostatic cancer cell through metabolic shift from oxidative phosphorylation to aerobic glycolysis. UK5099 suppresses proliferation and arrested LnCap cell cycle at G1/G0.
In vivo
UK-5099 slows the growth of patient-derived xenograft (PDX) tumors in mice without severe loss of animal body weight.
References
Synonyms
2-Propenoic acid, 2-cyano-3-(1-phenyl-1H-indol-3-yl)-
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
UK 5099
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-acrylic acid
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