[CAS NO. 636-00-0] Oxidopamine hydrobromide
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PRODUCTS SPECIFICATIONS [636-00-0]
Store
Catalog
SLK-S5324
Brand
Selleck
CAS
636-00-0
DESCRIPTION [636-00-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 250.09 |
| Molecular Formula | C8H11NO3.HBr |
| SMILES | C(CN)C1=C(O)C=C(O)C(O)=C1.Br |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9986 mL | 19.9928 mL | 39.9856 mL |
| 5 mM | 0.7997 mL | 3.9986 mL | 7.9971 mL |
| 10 mM | 0.3999 mL | 1.9993 mL | 3.9986 mL |
| 50 mM | 0.0800 mL | 0.3999 mL | 0.7997 mL |
Description
Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter with potential antineoplastic activity.
In vitro
In PC12 cells, 6-hydroxydopamine (6-OHDA) results in the activation of caspases and apoptosis, also induces superoxide generation, Bid cleavage and mitochondrial membrane depolarization.In addition, Akt phosphorylation that is favorable to cell survival is decreased and p38 MAPK phosphorylation is increased by 6-OHDA.
References
Synonyms
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide
6-Hydroxydopamine hydrobromide
6-Hydroxydopamine hydrogen bromide
2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide
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