[CAS NO. 189188-57-6] Tegaserod Maleate

Name: Tegaserod Maleate
Brand: Arctom Scientific
SKU: SLK-S5401

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PRODUCTS SPECIFICATIONS [189188-57-6]

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Catalog

SLK-S5401

Brand

Selleck

CAS

189188-57-6

DESCRIPTION [189188-57-6]

Overview

MDL	MFCD04116201
Molecular Weight	417.46
Molecular Formula	C16H23N5O.C4H4O4
SMILES	C(=C\C(O)=O)\C(O)=O.C(=NNC(NCCCCC)=N)C=1C=2C(NC1)=CC=C(OC)C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3954 mL	11.9772 mL	23.9544 mL
5 mM	0.4791 mL	2.3954 mL	4.7909 mL
10 mM	0.2395 mL	1.1977 mL	2.3954 mL
50 mM	0.0479 mL	0.2395 mL	0.4791 mL

Description

Tegaserod Maleate(HTF-919) is a hydrogen maleate salt form of tegaserod, which is a partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors, muscarinic, adrenergic, dopaminergic or opiate receptors.

Targets

5-HT4 receptor ^[1]

In vitro

In guinea-pig and rat colon, luminal application of tegaserod activates 5-HT4 receptors on intrinsic primary sensory neurons that release calcitonin gene-related peptide which in turn activates cholinergic interneurons stimulating the peristaltic reflex. In isolated segments of guinea-pig colon, intralumnal tegaserod increased the velocity of propulsion of artificial faecal pellets through the stimulation of the same receptor. In rat distal colon, intraluminal tegaserod stimulated 5-HT4 4 receptors on colonocytes to secrete chloride and water through an adenylyl cyclase-dependent pathway.

References

[1] Corsetti M, et al. Expert Opin Pharmacother. 2002, 3(8):1211-8.

Synonyms

Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)

Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (Z)-2-butenedioate (1:1)

SDZ-HTF 919

Zelmac

HTF 919

Zelnorm

Tegaserod maleate

Tegaserod hydrogen maleate

Tegibs 6