[CAS NO. 314041-08-2] Ellagic Acid hydrate
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PRODUCTS SPECIFICATIONS [314041-08-2]
Store
Catalog
SLK-S5516
Brand
Selleck
CAS
314041-08-2
DESCRIPTION [314041-08-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 320.21 |
| Molecular Formula | C14H6O8.H2O |
| SMILES | O=C1OC2=C(C3=C1C=C(O)C(O)=C3OC4=O)C4=CC(O)=C2O.[H]O[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1230 mL | 15.6148 mL | 31.2295 mL |
| 5 mM | 0.6246 mL | 3.1230 mL | 6.2459 mL |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
Ellagic acid is a potent inhibitor of with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.
In vitro
Ellagic acid (EA) is able to inhibit the growth of several cancer cells. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax : Bcl-2 ratio and restored anoikis in ES-2 and PA-1 cells. It is well known to have a free radical scavenging activity. EA reversed epithelial to mesenchymal transition by up-regulating E-cadherin and down-regulating Vimentin.
In vivo
A 90-day subchronic toxicity study further demonstrated that orally feeding EA (9.4, 19.1, 39.1 g/kg b.w., resp.) could not induce mortality or treatment-related clinical signs throughout the experimental period on F344 rats, indicating the low toxicity of EA to mammalians. Furthermore, EA exhibits potent anticancer and anticarcinogenesis activities towards breast, colorectal, oral, prostate, pancreatic, bladder, neuroblastoma, melanoma, and lymphoma cells. Treatment of PANC-1 xenografted mice with EA resulted in significant inhibition in tumor growth and prolong mice survival rate.
References
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