[CAS NO. 92-43-3]  Phenidone

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PRODUCTS SPECIFICATIONS [92-43-3]

Store
Catalog
SLK-S5520
Brand
Selleck
CAS
92-43-3

DESCRIPTION [92-43-3]

Overview

MDLMFCD00003094
Molecular Weight162.19
Molecular FormulaC9H10N2O
SMILESO=C1NN(CC1)C2=CC=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM6.1656 mL30.8280 mL61.6561 mL
5 mM1.2331 mL6.1656 mL12.3312 mL
10 mM0.6166 mL3.0828 mL6.1656 mL
50 mM0.1233 mL0.6166 mL1.2331 mL

Description

Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of and , is an organic compound that is primarily used as a photographic developer.

Targets

COX [1]LOX [1]

In vivo

Phenidone has provided neuroprotection in various experimental paradigms of neurodegeneration including kainate-induced excitotoxicity, ischemia, microglia-mediated neurotoxicity, and autoimmune encephalomyelitis. However, the neuroprotective effect of the compound appeared to be associated not only with inhibition of COX and LOX activities but also with its direct antioxidant property. Microglia-related neurotoxicity is believed to be partially mediated by oxidative/nitrosative stress.


Synonyms

3-Pyrazolidinone, 1-phenyl-
2-Pyrazolin-3-ol, 1-phenyl-
1-Phenyl-3-pyrazolidinone
Phenidone
1-Phenyl-3-oxopyrazolidine
1-Phenyl-3-pyrazolidone
Fenidon
1-Phenylpyrazolidine-3-one
1-Phenyl-4,5-dihydro-1H-pyrazol-3-ol