[CAS NO. 960404-48-2] Dapagliflozin propanediol monohydrate

Name: Dapagliflozin propanediol monohydrate
Brand: Arctom Scientific
SKU: SLK-S5566

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PRODUCTS SPECIFICATIONS [960404-48-2]

Store

Catalog

SLK-S5566

Brand

Selleck

CAS

960404-48-2

DESCRIPTION [960404-48-2]

Overview

MDL	MFCD28167768
Molecular Weight	502.98
Molecular Formula	C21H25ClO6.C3H8O2.H2O
SMILES	[C@@H](CO)(C)O.O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as inhibitors.

Targets

SGLT2 ^[1]

In vitro

Dapagliflozin is a small-molecule inhibitor of SGLT2 that has been shown to be highly selective for SGLT2 compared with other SGLT family members and to have no off-target interactions in an in vitro screen of more than 330 receptors, enzymes, ion channels, and transporters.

In vivo

Dapagliflozin demonstrates good oral bioavailability, has a high volume of distribution, and has an in vivo metabolite profile that is qualitatively similar between preclinical species and humans. Both non-clinical and clinical assessments have shown dapagliflozin to have a highly favorable safety profile that is consistent with its simple mechanism of action, with no off-target effects observed.

References

[1] Reilly TP, et al. Diabetes Ther. 2014, 5(1):73-96.

Synonyms

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, compd. with (2S)-1,2-propanediol, hydrate (1:1:1)

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, compd. with (2S)-1,2-propanediol (1:1), monohydrate

(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (S)-propane-1,2-diol (1:1) monohydrate

Dapagliflozin (S)-propylene glycol hydrate

Edistride

Farxiga

Dapagliflozin propanediol monohydrate

Forxiga