[CAS NO. 87233-61-2] Emedastine

Name: Emedastine
Brand: Arctom Scientific
SKU: SLK-S5659

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PRODUCTS SPECIFICATIONS [87233-61-2]

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Catalog

SLK-S5659

Brand

Selleck

CAS

87233-61-2

DESCRIPTION [87233-61-2]

Overview

MDL	MFCD00865647
Molecular Weight	302.41
Molecular Formula	C17H26N4O
SMILES	C(COCC)N1C(=NC=2C1=CC=CC2)N3CCCN(C)CC3

For research use only.

Storage

2 years -20°C liquid
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Emedastine is a potent, high affinity antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).

Targets

H1 receptor ^[1]
(Cell-free assay)

1.3 nM(Ki)

In vitro

Emedastine is capable of potently inhibiting histamine-induced cytokine release as well as the chemotaxis of eosinophils, thereby influencing factors contributing to the inhibition of the signs and symptoms of allergic diseases.

In vivo

In human, the half-life of emedastine, when administered as slow release capsules is of about 6±7 h.

References

[1] Sharif NA, et al. J Ocul Pharmacol. 1994, 10(4):653-64.
[2] Jansen B1, et al. Eur J Clin Pharmacol. 2000, 55(11-12):837-41.

Synonyms

1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-

1H-1,4-Diazepine, 1H-benzimidazole deriv.

1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole

Emedastine

1-Methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane