[CAS NO. 315705-75-0] JNJ0966
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PRODUCTS SPECIFICATIONS [315705-75-0]
Store
Catalog
SLK-S5696
Brand
Selleck
CAS
315705-75-0
DESCRIPTION [315705-75-0]
Overview
| MDL | MFCD02045222 |
|---|---|
| Molecular Weight | 360.45 |
| Molecular Formula | C16H16N4O2S2 |
| SMILES | CC(NC1=NC(C)=C(C2=CSC(NC3=CC=CC=C3OC)=N2)S1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
JNJ0966 is a highly selective compound that inhibits activation of and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
In vitro
JNJ0966 inhibits the conversion of proMMP-9 to active MMP-9 but is not a direct inhibitor of MMP-9 or MMP-3 enzymatic activity. JNJ0966 inhibits proMMP-9 maturation.
In vivo
Oral administration of JNJ0966 significantly diminishes the clinical disease score observed in the mouse EAE model.
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