[CAS NO. 135729-61-2] Palonosetron

Name: Palonosetron
Brand: Arctom Scientific
SKU: SLK-S5740

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PRODUCTS SPECIFICATIONS [135729-61-2]

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Catalog

SLK-S5740

Brand

Selleck

CAS

135729-61-2

DESCRIPTION [135729-61-2]

Overview

MDL	MFCD07783848
Molecular Weight	296.41
Molecular Formula	C19H24N2O
SMILES	O=C1C2=C3[C@@](CN1[C@H]4C5CCN(C4)CC5)(CCCC3=CC=C2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3737 mL	16.8685 mL	33.7371 mL
5 mM	0.6747 mL	3.3737 mL	6.7474 mL
10 mM	0.3374 mL	1.6869 mL	3.3737 mL
50 mM	0.0675 mL	0.3374 mL	0.6747 mL

Description

Palonosetron (RS25259, RS 25259 197) is a antagonist with value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Targets

5-HT3 receptor ^[2]

0.17 nM(Ki)

In vitro

Palonosetron is a 5-HT3 receptor antagonist with a high binding affinity for this receptor and little or no affinity for other receptors.

References

[1] Rudolph M Navari. Cancer Manag Res. 2009, 1: 167-176.
[2] Price KL, et al. ACS Chem Neurosci. 2016, 7(12):1641-1646.

Synonyms

1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aS)-

1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, [S-(R*,R*)]-

(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one

Palonosetron

(-)-Palonosetron