[CAS NO. 28822-58-4] IBMX

Name: IBMX
Brand: Arctom Scientific
SKU: SLK-S5836

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PRODUCTS SPECIFICATIONS [28822-58-4]

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Catalog

SLK-S5836

Brand

Selleck

CAS

28822-58-4

DESCRIPTION [28822-58-4]

Overview

MDL	MFCD00005584
Molecular Weight	222.24
Molecular Formula	C10H14N4O2
SMILES	C(C(C)C)N1C2=C(C(=O)N(C)C1=O)NC=N2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL
50 mM	0.0900 mL	0.4500 mL	0.8999 mL

Description

IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an antagonist.

Targets

PDE3 ^[1]	PDE4 ^[1]	PDE5 ^[1]
6.5 μM	26.3 μM	31.7 μM

In vitro

IBMX rescues PGE2-induced phosphorylation of AKT inhibited in cells from the EP4LysM mice, which protects against cAMP degradation.

References

[1] Wu BN, et al. Br J Pharmacol. 2004, 142(7):1105-14.
[2] Schroeder JA, et al. Behav Pharmacol. 2012, 23(3):310-4.
[3] Jiang W, et al. Bone Res. 2022;10(1):27.
[4] Hosseini A, et al. Iran J Basic Med Sci. 2012;15(4):916-925.

Synonyms

1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-

Xanthine, 3-isobutyl-1-methyl-

1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-

3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

1-Methyl-3-isobutylxanthine

3-Isobutyl-1-methylxanthine

Isobutylmethylxanthine

SC 2964

IBMX

Methylisobutylxanthine

IMX

NSC 165960

1-Methyl-3-(2-methylpropyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione

3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione

3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione