[CAS NO. 2922-83-0] L-Kynurenine

Name: L-Kynurenine
Brand: Arctom Scientific
SKU: SLK-S5839

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PRODUCTS SPECIFICATIONS [2922-83-0]

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Catalog

SLK-S5839

Brand

Selleck

CAS

2922-83-0

DESCRIPTION [2922-83-0]

Overview

MDL	MFCD00069912
Molecular Weight	208.21
Molecular Formula	C10H12N2O3
SMILES	C(C[C@@H](C(O)=O)N)(=O)C1=C(N)C=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL

Description

L-Kynurenine ((S)-Kynurenine) is a agonist. L-Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway.

In vitro

Kynurenine (Kyn), the tryptophan (Trp) metabolite and an AHR ligand in hepatocytes, accumulates to cellular levels to cause an elevated rate of AHR activation, and stimulates AHR transcriptional activity quickly. An excess production of Kyn via increased cellular IDO1 levels and activity leads to amplified AHR signaling ultimately giving rise to obesity.

References

[1] Moyer, et al. Toxicology and applied pharmacology vol. 300 (2016): 13-24.
[2] Nozaki K, et al. J Cereb Blood Flow Metab. 1992 May;12(3):400-7.

Synonyms

Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αS)-

Alanine, 3-anthraniloyl-, L-

Benzenebutanoic acid, α,2-diamino-γ-oxo-, (S)-

(αS)-α,2-Diamino-γ-oxobenzenebutanoic acid

L-Kynurenine

L-3-(o-Aminobenzoyl)alanine

Kynurenine

Kynurenin

3-Anthraniloylalanine

(2S)-4-(2-Aminophenyl)-2-azaniumyl-4-oxobutanoate