[CAS NO. 81409-90-7] Cabergoline

Name: Cabergoline
Brand: Arctom Scientific
SKU: SLK-S5842

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PRODUCTS SPECIFICATIONS [81409-90-7]

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Catalog

SLK-S5842

Brand

Selleck

CAS

81409-90-7

DESCRIPTION [81409-90-7]

Overview

MDL	-
Molecular Weight	451.60
Molecular Formula	C26H37N5O2
SMILES	C(C=C)N1[C@]2([C@@](C=3C=4C(C2)=CNC4C=CC3)(C[C@@H](C(N(C(NCC)=O)CCCN(C)C)=O)C1)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2143 mL	11.0717 mL	22.1435 mL
5 mM	0.4429 mL	2.2143 mL	4.4287 mL
10 mM	0.2214 mL	1.1072 mL	2.2143 mL
50 mM	0.0443 mL	0.2214 mL	0.4429 mL

Description

Cabergoline (FCE-21336), an ergot derivative, is a long-acting agonist and inhibitor.

Targets

D2 receptor ^[1]	5-HT2 ^[1]	5-HT2B ^[1]	D3 receptor ^[1]	D4 receptor ^[1]
0.7 nM	1.2 nM	1.2 nM	1.5 nM	9 nM

In vitro

Cabergoline prevents the oxidative stress-induced cell death of cultured cortical neurons via a D2 receptor-mediated mechanism. Cabergoline suppresses the activation of ERK signaling, which might have a role in the neuroprotection. Cabergoline significantly represses extracellular glutamate accumulation triggered by oxidative stress, and increases the expression of glutamate transporters including EAAC1, which is known to be involved in the clearance of extracellular glutamate.

In vivo

Cabergoline has a long elimination half-life (63 to 109 h). An in vivo study of neuronal damage induced by intracerebroventricular (icv) injection of 6-OHDA, a neurotoxic compound that selectively damages dopaminergic neurons in male ICR mice, demonstrates that intraperitoneal (ip) administration of cabergoline for 7 days prevented nigrostriatal region dopaminergic neurons from cell death. Cabergoline also protects SH-SY5Y neuroblastoma from cell death by oxygen-glucose deprivation even when cabergoline is administered after the induction of cell death. Cabergoline increases hippocampal brain-derived neurotrophic factor (BDNF, an important regulator in the synaptic plasticity) and exerts an antidepressant effect in rats.

References

[1] Haruki Odaka, et al. PLoS One. 2014, 9(6): e99271.

Synonyms

Ergoline-8-carboxamide, N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-, (8β)-

Ergoline-8-carboxamide, N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-, (8β)-

(8β)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)ergoline-8-carboxamide

Cabergoline

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